Synthesis and antimycobacterial activity of disubstituted benzyltriazoles
نویسندگان
چکیده
منابع مشابه
Synthesis and antimycobacterial activity of some N,N′-disubstituted isonicotinohydrazide derivatives
A new series of antimycobacterial agents 2a–j, 3a–d, 6b–f,j, and 7b,f was designed, synthesized and evaluated for antimycobacterial activity against different mycobacterium species i.e. M. tuberculosis, M. avium, and M. intracellulare in an agar dilution method. Some of these compounds (2e, 3a–d) were highly potent with in vitro activity against M. tuberculosis H37Rv and clinical isolates (sens...
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A series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplate alamar blu...
متن کاملSynthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
A series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplate alamar blu...
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To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...
متن کاملNovel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies
To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...
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ژورنال
عنوان ژورنال: Medicinal Chemistry Research
سال: 2019
ISSN: 1054-2523,1554-8120
DOI: 10.1007/s00044-019-02458-7